Endocrine Abstracts

Aim: – to study the functional status of pituitary-gonades-cortex (PGC) axis in women with Cushing syndrome (CS)Materials and methods: Weevaluated 25 women with ACTH-depended CS without other associated pathology. Mean age of patients was 28,3 years-old\. All patients have complaints to amenorrhea and primary infertility. Control group constituted by 20 healthy women with same age All patients underwent clinical and biochemical evaluations including...

Early diagnostics it is IPA treats difficult questions of a modern neuroendocrinology as even highly informative computer tomographs and the magnetic resonant imaging (MRI) don’t give the correct answer to 30–55% of cases, and at microadenomas to 90% of cases.The purpose: Studying of structure it is IPA at MRI-research at patients with the verified diagnosis.Material and methods: Research included 325 patients with is IPA...

Objective: Diagnosis of primary hyperaldosteron in patients with malignant arterial hypertension.Materials and methods: The study included 125 patients with hypertension (68 men, 57 women, ages 16–74). All patients underwent biochemical hormonal analyzes of blood and ECG, MSCT. All patients tested ARS, out of 125 in 18 patients with ARS> 30. Patients with primary hyper aldosteronism 18 of them women 7, men 11, patients age 34±8.8 years, hyp...

At IPA development of a tumor leads to various of pituitary dysfunction, including violates the gonadotropic function of the pituitary gland and there are disorders of sexual and reproductive function. The purpose of our research was studying of a condition of sexual system and gonadotropic function of a hypophysis at patients with is IPA.Results and discussion: In the analysis of a condition of sexual system at 126 women with it is IPA to 50-year age th...

The aim: To study case of partial gigantism.Methods: To evaluate the patient’s condition we conducted hormonal and biochemical investigations, as well as total blood and clinical urine analysis; Doppler sonography and multislice computed tomography were performed.Results: STH – 25.8 mIU/l (normal range: 2.0–20 mIU/l); IGF – 2.9 mg/l (normal range for the age: 13–100 mg/l); ALPase – 160 U/l (normal rang...

The aim: To study the case of Pachydermoperiostosisis.Material and methods: We report a case of a 24-year old male complaining of marked changes in appearance due to the disfiguring thickening and wrinkling of skin, excessive greasiness and perspiration, marked horizontal creases on the forehead, with deep furrows between them, increase in the thickness of eye lids, “senile expression” of the face, thickening of distal parts of extremities, fin...

Aim: The work was initiated to study prolactin levels in hormonally inactive pituitary adenoma by the size of the tumor.Material and methods: We examined 85 patients with hormonally inactive pituitary adenomas, 45 women and 40 men among them aged from 18 to 50 years (mean age 44.5±3.85 years). The disease duration from the onset to diagnosis based on the medical history and MRI ranged from 1 to 15 years.Results and discussion:...

The purpose of the study: To examine the incidence of neuroendocrine complications after radiation therapy (RT) of pituitary somatotropinomas.Materials and methods: 30 patients surveyed after receiving RT at a dose of 45 g in 25 fractions a day. Of these, 21 (70%) females, 9 (30%) men. The age of patients ranged from 36 to 71 years. 37% of them had pituitary macroadenoma with para-, supra-, and infrasellar growth. Duration of illness was 15 years on aver...

Aim of this study was to investigate the incidence of Cushing’s syndrome (CS) in women with polycystic ovary syndrome.Materials and methods: The study involved 35 women from 17 to 39 years with verified diagnosis of PCOS according to the Rotterdam Consensus (2003). First group – 26 women with PCOS and BMI≥25 kg/m2 and second group – control – nine women with PCOS and BMI≤25−18 kg/m2. Investigate...

The objective was to study clinical aging peculiarities of manifestation period of cortisol secreting adrenal adenoma.Materials and methods: Forty five patients with cortisol-secreting adrenal adenoma served the basis for the study. In that group of patients there were 11 (24.4%) men and 34 (75.6%) women, with the average age 27.5 ± 10.5 years old. Out of forty five patients 5 (11.2%) were children. All patients had common clinical, biochemical, hor...